WFS1 Antibody (C3) - BSA Free

Novus Biologicals | Catalog # NBP3-42154

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # C3

Format

BSA Free
View all WFS1 Primary Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human WFS1 (Uniprot#: O76024; Met1-Lys300 (Uniprot#: O76024)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for WFS1 Antibody (C3) - BSA Free

WFS1 Antibody (C3)

Western Blot: WFS1 Antibody (C3) [NBP3-42154] -

Western Blot: WFS1 Antibody (C3) [NBP3-42154] - Sample: Lane1: Rat Cerebrum lysate; Lane2: Mouse Cerebrum lysate; Lane3: Human Placenta lysate Primary Ab: 1ug/ml NBP3-42154; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody

Applications for WFS1 Antibody (C3) - BSA Free

Application
Recommended Usage

Western Blot

0.5-2ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Format

BSA Free

Preservative

0.05% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: WFS1

Wolframin (WFS1) is a multipass endoplasmic reticulum (ER) membrane protein that plays an important role in maintaining homeostasis of the ER in the pancreas. WFS1 helps to regulate cellular calcium cation homeostasis by altering the filling state of the ER calcium cation store.

WFS1 is the major component of Wolfram syndrome, a rare form of juvenile diabetes, also known as diabetes insipidus and mellitus with optic atrophy and deafness syndrome (DIDMOAD). WFS1 is normally up-regulated during insulin secretion, and inactivation of the protein causes ER stress. In turn, chronic ER stress is thought to play a major role in Wolfram syndrome.

Long Name

Wolfram Syndrome 1

Alternate Names

DFNA14, DFNA38, DFNA6, DIDMOAD, WFRS, Wolframin

Gene Symbol

WFS1

Additional WFS1 Products

Product Documents for WFS1 Antibody (C3) - BSA Free

Certificate of Analysis

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Product Specific Notices for WFS1 Antibody (C3) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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