WM 1119

Key Product Details

Product Description

WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (K_d = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC₅₀ = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.

Licensing Information

Sold under license from Monash University

External Portal Information

Chemicalprobes.org

and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.

Product Specifications for WM 1119

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WM 1119

The following data is based on the product molecular weight 389.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Baell Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 2018 PMID: 30069049

Product Documents for WM 1119