WQ 1

Key Product Details

Product Description

WQ 1 is a high affinity and selective σ1 receptor antagonist (pK_i values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.

Product Specifications for WQ 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WQ 1

The following data is based on the product molecular weight 337.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.93 mL	29.63 mL	59.26 mL
2.5 mM	1.19 mL	5.93 mL	11.85 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
25 mM	0.12 mL	0.59 mL	1.19 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Piergentili Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J.Med.Chem. 2010 PMID: 20067271
• Bello Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane. ACS Chem.Neurosci. 2019 PMID: 31298830

Product Documents for WQ 1