WY 14643

Key Product Details

Product Description

WY 14643 is a selective PPARα agonist (EC₅₀ values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

Product Specifications for WY 14643

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WY 14643

The following data is based on the product molecular weight 323.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.44 mL	30.88 mL
5 mM	0.62 mL	3.09 mL	6.18 mL
10 mM	0.31 mL	1.54 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

• Forman Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc.Natl.Acad.Sci.U.S.A. 1997 PMID: 9113986
• Willson The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 2000 PMID: 10691680
• Bishop-Bailey Peroxisome proliferator-activated receptors in the cardiovascular system. Br.J.Pharmacol. 2000 PMID: 10696077

Product Documents for WY 14643