Xanthohumol

Key Product Details

Product Description

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC₅₀ = 50.3 μM).

Product Specifications for Xanthohumol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Xanthohumol

The following data is based on the product molecular weight 354.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.11 mL	28.22 mL
5 mM	0.56 mL	2.82 mL	5.64 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Tabata Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. Phytochemistry 1997 PMID: 9366096
• Inokoshi Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J.Antibiot.(Tokyo) 2009 PMID: 19132064
• Sasazawa Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein. ACS Chem.Biol. 2012 PMID: 22360440

Product Documents for Xanthohumol