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XMD 8-87

Catalog #: 6061 Datasheet / COA / SDS

Discontinued Product

6061 has been discontinued.
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XMD 8-87 | CAS No. 1234480-46-6 | Ack1 Inhibitors
1 Image
Description: Potent Ack1/TNK2 inhibitor

Chemical Name: 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

XMD 8-87 is a potent Ack1/TNK2 inhibitor (IC50 = 38 and 113 nM in Ba/F3 cell lines containing leukemia-associated D163E and R806Q mutations respectively). Blocks phosphorylation of TNK2 receptors containing solid-tumor type truncation mutations.

Technical Data

M.Wt:
445.52
Formula:
C24H27N7O2
Solubility:
Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1234480-46-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis.
    Maxson et al.
    Cancer.Res., 2015;76:127
  2. Development and repurposing of small-molecule kinase inhibitors to target novel leukemogenic TNK2 mutations
    Maxson et al.
    Blood, 2014;124:435

Product Datasheets

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