YIL 781 hydrochloride

Name: YIL 781 hydrochloride
Brand: Tocris Bioscience
SKU: 3959
Price: 589 USD
Availability: InStock

Tocris Bioscience | Catalog # 3959

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Citations (6)

Product Documents

Ghrelin receptor (GHS-R1a) antagonist

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Ghrelin receptor (GHS-R1a) antagonist

View all Ghrelin Receptor Antagonists »

Product Description

YIL 781 hydrochloride is a ghrelin receptor antagonist (GHS-R1a) (K_i = 17 nM). Displays no significant affinity for the motilin receptor (K_i = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.

Product Specifications for YIL 781 hydrochloride

Molecular Weight

445.96

Formula

C₂₄H₂₈FN₃O₂.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride

CAS Number

1640226-17-0

PubChem ID

74889155

InChI Key

QQGRMONBDBMLSP-FERBBOLQSA-N

SMILES

O=C2C1=CC(OC4=CC=C(F)C=C4)=CC=C1N=C(C)N2C[C@@H]3CN(C(C)C)CCC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.6	100
	DMSO	44.6	100

Preparing Stock Solutions for YIL 781 hydrochloride

The following data is based on the product molecular weight 445.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.21 mL	22.42 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

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Mass

Concentration

音量

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Moran and Dailey Gut peptides: targets for antiobesity drug development? Endocrinology 2009 PMID: 19372201
Esler Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology 2007 PMID: 17656463

Product Documents for YIL 781 hydrochloride

Download SDS

Product Specific Notices for YIL 781 hydrochloride

For research use only

Related Research Areas

Nutrition and Appetite

Obesity

Citations for YIL 781 hydrochloride

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