YK 3-237

Key Product Details

Product Description

YK 3-237 is a SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G₂/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.

Product Specifications for YK 3-237

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YK 3-237

The following data is based on the product molecular weight 372.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.43 mL	26.87 mL
5 mM	0.54 mL	2.69 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ponnusamy Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 2015 PMID: 26022003
• Yi Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 2013 PMID: 23846322

Product Documents for YK 3-237