YM 26734

Tocris Bioscience | Catalog # 2522

Secretory phospholipase A2 (sPLA2) inhibitor
Tocris Bioscience
Discontinued Product
2522 has been discontinued. View all Phospholipase Inhibitors products.

Key Product Details

Description

Secretory phospholipase A2 (sPLA2) inhibitor
View all Phospholipase Inhibitors »

Product Description

YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Product Specifications for YM 26734

Molecular Weight

730.97

Formula

C45H62O8

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone

CAS Number

144337-18-8

PubChem ID

9853400

InChI Key

CEJAYJCUSZHYDS-UHFFFAOYSA-N

SMILES

OC1=C(C2CC(C4=CC=C(O)C=C4)OC3=C2C=CC(O)=C3)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 73.1 100
Ethanol 73.1 100

Preparing Stock Solutions for YM 26734

The following data is based on the product molecular weight 730.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.37 mL 6.84 mL 13.68 mL
5 mM 0.27 mL 1.37 mL 2.74 mL
10 mM 0.14 mL 0.68 mL 1.37 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for YM 26734

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for YM 26734

For research use only

Related Research Areas

Bioactive Lipids and Receptors

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