YM 298198 hydrochloride

Key Product Details

Product Description

YM 298198 hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu₁ receptors (K_i = 19 nM); inactive at other mGlu receptor subtypes (mGlu_2-7), ionotropic receptors and glutamate transporters (IC₅₀ > 10 μM). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC₅₀ values are 16 nM and 6.3 μM respectively), and is orally active in vivo, demonstrating an antinociceptive effect in hyperalgesic mice.

Desmethyl Derivative also available.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Product Specifications for YM 298198 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YM 298198 hydrochloride

The following data is based on the product molecular weight 378.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.20 mL	26.39 mL
5 mM	0.53 mL	2.64 mL	5.28 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 54 publications citing the usage of this product.

• Emery The protective signaling of metabotropic glutamate receptor 1 is mediated by sustained, β-arrestin-1-dependent ERK phosphorylation. J.Biol.Chem. 2010 PMID: 20566651
• Kohara Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective and noncompetitive antagonist of metabo J.Pharmacol.Exp.Ther. 2005 PMID: 15976016

Product Documents for YM 298198 hydrochloride