YNT 185

Key Product Details

Product Description

YNT 185 is a potent and selective orexin OX₂ receptor agonist (EC₅₀ = 28 nM at human OX₂ expressed in CHO cells). Displays approximately 100-fold selectivity for OX₂ over OX₁ (EC₅₀ = 2.75 μM at human OX₁ expressed in CHO cells). Depolarizes OX₂-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

Product Specifications for YNT 185

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YNT 185

The following data is based on the product molecular weight 688.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.45 mL	7.26 mL	14.52 mL
5 mM	0.29 mL	1.45 mL	2.90 mL
10 mM	0.15 mL	0.73 mL	1.45 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Irukayama-Tomobe Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 2017 PMID: 28507129
• Nagahara Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 2015 PMID: 26267383

Product Documents for YNT 185