Yoda 2

Tocris Bioscience | Catalog # 8051

Piezo1 channel activator
Tocris Bioscience

Key Product Details

Description

Piezo1 channel activator
View all Piezo Channel Activators »

Product Description

Yoda 2 is a selective Piezo1 channel activator (EC50 values are 150 nM and 1.14 μM in mPiezo1 and HUVEC cells respectively). Increases Ca2+ signaling 2.8 fold in hPIEZO-TREx and 1.2 fold in mPIEZO1-TREx, compared to Yoda 1 (Cat. No. 5586). Induces concentration-dependent relaxation of mouse portal vein (EC50 = 1.2 μM). Suitable for use in vivo and in vitro.

Product Specifications for Yoda 2

Molecular Weight

435.38

Formula

C16H9Cl2N2O2S2K

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate

CAS Number

3081450-95-2

InChI Key

OQEIWUHZUPFUQU-UHFFFAOYSA-M

SMILES

O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 43.54 100
DMSO 21.77 50

Preparing Stock Solutions for Yoda 2

The following data is based on the product molecular weight 435.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.30 mL 11.48 mL 22.97 mL
5 mM 0.46 mL 2.30 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.30 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Yoda 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Yoda 2

For research use only

Customer Reviews for Yoda 2 (1)

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  • test
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 03/11/2025
    Yoda 2 is a selective activator for Piezo1 channel. Solubility is greatly enhanced compared to Yoda 1 and it works well in lower uM range in rat culture.

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