Zanamivir

Key Product Details

Product Description

Zanamivir is an influenza viral neuraminidase inhibitor (IC₅₀ values are 0.95 nM and 2.7 nM for influenza A and B, respectively). Inhibits neuraminidase, preventing the cleavage of sialic acid on the cell receptors, and release of the newly formed virions.

Product Specifications for Zanamivir

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zanamivir

The following data is based on the product molecular weight 332.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	60.18 mL	300.92 mL	601.85 mL
0.25 mM	12.04 mL	60.18 mL	120.37 mL
0.5 mM	6.02 mL	30.09 mL	60.18 mL
2.5 mM	1.20 mL	6.02 mL	12.04 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Elliott Zanamivir: from drug design to the clinic. Philos.Trans.R.Soc.Lond.B.Biol.Sci. 2001 PMID: 11779388
• McKimm-Breschkin Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir.Med. 2005 PMID: 15813662
• Gubareva Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob.Agents Chemother. 2001 PMID: 11709315

Product Documents for Zanamivir