Zaprinast

Key Product Details

Product Description

Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC₅₀ values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Product Specifications for Zaprinast

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zaprinast

The following data is based on the product molecular weight 271.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

12 11 10 9 8 7 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.43 mL	36.86 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

• Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.
• Soderling Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J.Biol.Chem. 1998 PMID: 9624145
• Taniguchi Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Lett. 2006 PMID: 16934253
• Lugnier Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol.Ther. 2006 PMID: 16102838

Product Documents for Zaprinast