Zatebradine hydrochloride

Key Product Details

Product Description

Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current I_f (HCN channel) in sinoatrial node cells (EC₅₀ = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC₅₀ of 13.4 μM).

Product Specifications for Zatebradine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Zatebradine hydrochloride

The following data is based on the product molecular weight 493.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.14 mL	20.28 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.20 mL	1.01 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Goethals Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 1993 PMID: 8222132
• Romanelli Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current. Bioorg.Med.Chem. 2005 PMID: 15670930
• Van Bogaert Use- and frequency-dependent blockade by UL-FS 49 of the i_f pacemaker current in sheep cardiac Purkinje fibres. Eur.J.Pharmacol. 1990 PMID: 2272362

Product Documents for Zatebradine hydrochloride