ZCL 278

Key Product Details

Product Description

ZCL 278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Product Specifications for ZCL 278

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZCL 278

The following data is based on the product molecular weight 584.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.71 mL	8.55 mL	17.10 mL
5 mM	0.34 mL	1.71 mL	3.42 mL
10 mM	0.17 mL	0.85 mL	1.71 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Friesland Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 2013 PMID: 23284167

Product Documents for ZCL 278