ZIP

Name: ZIP
Brand: Tocris Bioscience
SKU: 2549
Price: 292 USD
Availability: InStock

Tocris Bioscience | Catalog # 2549

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Citations (15)

Product Documents

Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Cell-permeable inhibitor of atypical PKC isozyme PKMζ

Alternative Names

z-Pseudosubstrate inhibitory peptide

View all Protein Kinase C Inhibitors »

Product Description

ZIP is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC₅₀ = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.

Control Peptide and Biotinylated Peptide also available.

Product Specifications for ZIP

Molecular Weight

1928.40

Formula

C₉₀H₁₅₄N₃₀O₁₇

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

863987-12-6

PubChem ID

16156119

InChI Key

CRKARHQCXWSUMV-HOHDCHNJSA-N

SMILES

[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Pastalkova Storage of spatial information by the maintenance mechanism of LTP. Science 2006 PMID: 16931766
Ling Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci.
Serrano Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 2005 PMID: 15728837

Product Documents for ZIP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ZIP

For research use only

Related Research Areas

Diabetes

Intracellular Kinases

Citations for ZIP

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