ZM 241385

Tocris Bioscience | Catalog # 1036

Potent and highly selective A2A antagonist
Tocris Bioscience

Key Product Details

Description

Potent and highly selective A2A antagonist
View all Adenosine A2a Receptor Antagonists »

Product Description

ZM 241385 is a potent and highly selective A2A adenosine antagonist, with a pA2 of 9.02 for A2A receptors in guinea pig cardiac vasculature and fold selectivities of 1000, 91 and 500,000 over A1, A2B and A3 sites respectively. Active in vivo. ZM 241385 suppresses the ERK1/2 pathway in human squamous carcinoma cells.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for ZM 241385

Molecular Weight

337.34

Formula

C16H15N7O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol

CAS Number

139180-30-6

PubChem ID

176407

InChI Key

PWTBZOIUWZOPFT-UHFFFAOYSA-N

SMILES

NC1=NC(NCCC2=CC=C(O)C=C2)=NC2=NC(=NN12)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.73 100
Ethanol 1.69 5

Preparing Stock Solutions for ZM 241385

The following data is based on the product molecular weight 337.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.30 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 467 publications citing the usage of this product.

Product Documents for ZM 241385

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ZM 241385

For research use only

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  • Mouse solenocytes
    Name: Tahmineh Safaie
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: solenocytes
    Verified Customer | Posted 10/09/2020
    Mouse solenocytes were activated with antiCD3/28 and treated with 5 uM of ZM241385 in presence or absence of CGS21680. After 24 hours the supernatant was collected, and IFN-gamma was measured by ELISA.
    ZM 241385 1036

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