ZM 449829

Key Product Details

Product Description

ZM 449829 is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC₅₀ values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Product Specifications for ZM 449829

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ZM 449829

The following data is based on the product molecular weight 182.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.49 mL	27.44 mL	54.88 mL
5 mM	1.10 mL	5.49 mL	10.98 mL
10 mM	0.55 mL	2.74 mL	5.49 mL
50 mM	0.11 mL	0.55 mL	1.10 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Orange IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 2011 PMID: 21383498
• Brown Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 2000 PMID: 10741557

Product Documents for ZM 449829