Zolpidem
Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Purity: ≥99%
Biological Activity
Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.
Morairty SR, Revel FG, Malherbe P
PLoS ONE, 2012;7(7):e39131. -
Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, Rudolph U, Swinny J
, 2014;0(0):. -
Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors.
Soderhielm et al.
Biochem.Pharmacol., 2018;158:339 -
Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects.
Depoortere et al.
J.Pharmacol.Exp.Ther., 1986;237:649 -
High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors.
Arbilla et al.
Eur.J.Pharmacol., 1986;130:257 -
Mechanism of action of the hypnotic zol. in vivo.
Crestani et al.
Br.J.Pharmacol., 2000;131:1251 -
Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zol.
Perrault et al.
J.Pharmacol.Exp.Ther., 1992;263:298
Product Datasheets
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Citations for Zolpidem
The citations listed below are publications that use Tocris products. Selected citations for Zolpidem include:
7 Citations: Showing 1 - 7
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Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin
Authors: Letra-Vilela Et al.
Molecular and Cellular Endocrinology 2016;434:238
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Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Authors: Seifi Et al.
Br J Cancer 2014;34:10361
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Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala.
Authors: Geracitano Et al.
Front Neural Circuits 2012;6:32
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Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity.
Authors: Lazarus and Huang
J Neurophysiol 2011;106:775
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Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
Authors: Kotak Et al.
J Neurosci 2008;18:2098
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From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors.
Authors: Wulff Et al.
Nat Neurosci 2007;10:923
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Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Authors: Bowser Et al.
Proc Natl Acad Sci U S A 2002;99:15170
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