Custom Targeted Protein Degradation Services
Get ahead with your Targeted Protein Degradation research by leveraging our unique range of Custom Services.
A Unique Range of Services for Targeted Protein Degradation Research
A unique portfolio of custom services supports your PROTAC® discovery, development and target validation programs. We have expertise in custom chemistry and can help you develop protein degraders to knock down your target of choice. Custom degrader building blocks and custom building block panels can assist you to build your own degraders. We also offer custom E3 ligase development services, which enable you to build your own assays to investigate ubiquitination in the presence of a degrader.
Browse Our Custom Services for PROTAC® Discovery and Research
Custom Degraders
We provide a wide range of off-the-shelf active degraders for your research, but if you can’t find what you’re looking for in our catalog, you can take advantage of our expertise in PROTAC® chemistry and partner with us for the custom design and synthesis of your active degrader of interest.
Custom Degrader Building Blocks
We can help you to build your own degraders by providing you with the building blocks you require. Our expert chemistry team is highly experienced in Degrader synthesis and can develop building blocks from different E3 ligase ligands and linkers of your choosing, not currently available off-the-shelf.
Custom E3 Ligases
Our Proteins Group provides superior quality Ubiquitin-Proteasome System Proteins/E3 Ligases enabling you to develop assays to investigate the activity of your Degraders on ubiquitination of substrate proteins. If you require a UPS Protein/E3 Ligase that is not on our website talk to our team about your research and take advantage of our industry leading experience in development and manufacturing of UPS proteins.
Customer Success Stories
"The Tocris team demonstrated an exceptional ability to solve challenging synthetic problems while preparing an array of complex PROTACs for us. Their commitment to quality was commendable, and their efforts led to the delivery of substantial compound quantities with excellent purities in a timely fashion."
Matthew Fyfe
Head of Chemistry at Sitryx Therapeutics
"We have been utilizing BMoGen [now R&D Systems] for the last two years to take on our most challenging gene engineering projects. They provide the most up-to-date engineering tools, strategies, and techniques to ensure the quickest turn-around of the final cells. The team really has some of the brightest and most tenacious scientists that treat our project as if it was their own research."
Senior Scientist
Fortune 25 Pharmaceutical Company, West Coast
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.