15-PGDH/HPGD Proteins and Enzymes

HPGD, or 15-hydroxyprostaglandin dehydrogenase, is a NAD⁺-linked dehydrogenase that oxidizes the hydroxyl group at position 15 of prostaglandins to a ketone, resulting in a loss of biological activity. HPGD is a major enzyme for the catabolism of prostaglandins. The enzyme is a member of the short-chain alcohol dehydrogenase family of en...