A20/TNFAIP3 Lysates

A20, also known as TNF-alpha-induced Protein 3 (TNFAIP3) is a 790 amino acid (aa) cytoplasmic protein with a predicted molecular weight of 90 kDa. It was originally described as a protein upregulated by TNF-alpha stimulation. Human A20/TNFAIP3 exhibits 88% aa sequence identity to its mouse ortholog. Structurally, it contains seven zinc finger domains, one of which has Ubiquitin ligase (E3) activity. The N-terminus contains a deubiquitinating enzyme (DUB) domain. As such, A20/TNFAIP3 can be ...