Additional Retinoic Acid Receptor Compounds

Retinoic acid receptors (RARs) are nuclear hormone receptors of the NR1B class, which function as heterodimers with retinoid X receptors (RXRs). There are three distinct RAR subtypes: RARα, RARβ and RARγ. RARα is present in most tissue types, whereas RARβ and RARγ expression is more selective.

RXR-RAR heterodimers act as ligand-dependent transcriptional regulators by binding to the specific retinoic acid response element (RARE) found in the promoter regions of ...