AIF Proteins and Enzymes

Apoptosis-inducing factor (AIF) is a 57-kDa flavoprotein, with orthology to bacterial oxidoreductases, that is localized to the mitochondria. Mitochondria play a key role in the regulation of apoptosis. AIF is released into the cytosol, translocated to the nucleus, and initiates chromatin condensation as part of the intrinsic Caspase-9-mediated apo...