Aminopeptidase Inhibitors

Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues whilst arginyl aminopeptidase releases arginine and lysine residues. Aminopeptidases are generally classed as metalloproteases, and are often associated with zinc.

Aminopeptidases were some of the earliest proteases characterized. They are classified by various ...