ATP6V0E2 Products

Multisubunit vacuolar-type proton pumps, or H(+)-ATPases, acidify various intracellular compartments, such as vacuoles,clathrin-coated and synaptic vesicles, endosomes, lysosomes, and chromaffin granules. H(+)-ATPases are also found inplasma membranes of specialized cells, where they play roles in urinary acidification, bone resorption, and spermmaturation. Multiple subunits form H(+)-ATPases, with proteins of the V1 class hydrolyzing ATP for energy to transportH+, and proteins of the V0 class forming an integral membrane domain through which H+ is transported. ATP6V0E2 encodesan isoform of the H(+)-ATPase V0 e subunit, an essential proton pump component (Blake-Palmer et al., 2007 (PubMed17350184)).(supplied by OMIM)