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12 results for "BRD3 Small Molecules and Peptides" in 产品

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BRD3 Small Molecules and Peptides

BRD3 was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known.

(+)-JQ1

Catalog #: 4499

(2)

Citations (43)

Product Documents

Potent and selective BET bromodomain inhibitor; cell permeable

Chemical Name:	(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Purity:	≥98%

MZ 1

Catalog #: 6154

Citations (18)

Product Documents

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Chemical Name:	(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98%

I-BET 151 dihydrochloride

Catalog #: 4650

(2)

Citations (9)

Product Documents

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

Chemical Name:	7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride
Purity:	≥98%

dBET1

Catalog #: 6327

Citations (3)

Product Documents

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name:	(6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98%

dBET6

Catalog #: 6945

Citations (5)

Product Documents

Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name:	(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98%

Bromosporine

Catalog #: 4758

Citations (2)

Product Documents

Broad spectrum bromodomain inhibitor

Chemical Name:	N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
Purity:	≥98%

CPI 203

Catalog #: 5331

(1)

Citations (3)

Product Documents

BET bromodomain inhibitor; arrests cell cycle at G1 phase

Alternate Names:	TEN 010
Chemical Name:	(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98%

OTX 015

Catalog #: 6181

Citations (6)

Product Documents

BET bromodomain inhibitor; orally bioavailable

Alternate Names:	Birabresib
Chemical Name:	(6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98%

I-BET 762

Catalog #: 6521

Citations (1)

Product Documents

Potent and high affinity BET bromodomain inhibitor; anti-inflammatory; orally bioavailable.

Alternate Names:	GSK525762A,Molibresib
Chemical Name:	(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
Purity:	≥98%

ARV 771

Catalog #: 7256

Citations (1)

Product Documents

Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells

Chemical Name:	(2S,4R)-1-((S)-2-(tert-Butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Purity:	≥98%