6 results for "Ca2+-Activated Potassium Channel Blockers Small Molecules and Peptides" in 产品
Ca2+-Activated Potassium Channel Blockers Small Molecules and Peptides
There are 8 members of the KCa channel family, all of which are homo or heterotetramers of α-subunits, with either 6 or 7 transmembrane domains. Some family members also have associated regulatory subunits. KCa1.1 (BK), KCa2.x (SK) and KCa3.1 (IK) ion channels open in response to intracellular Ca2+ levels. Other KCa family members, KCa4.1, KCa4.2 (now known as KNa1.1 and KNa1.2) and KCa5.1 are grouped with KCa1.1 (BK) based on their structural similarities, however relatively little is ...
KCa2 (SK) channel blocker
| Purity: | ≥95% |
SERCA ATPase blocker. Also potent BKCa channel blocker
| Chemical Name: | (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one |
| Purity: | ≥98% |
KCa (BK) channel blocker
| Purity: | ≥95% |
Highly potent KCa2 (SK) channel blocker
| Chemical Name: | 6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide |
| Purity: | ≥97% |
Potent and highly selective KCa3.1 (IK) channel blocker
| Chemical Name: | 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole |
| Purity: | ≥98% |
Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
| Chemical Name: | N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride |
| Purity: | ≥98% |
