CaM Kinase Inhibitors

Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca²⁺. At basal Ca²⁺ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca²⁺ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity.

There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) ...