Casein Kinase 1 Degraders

Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: α, β, γ1, γ2, γ3, δ and ε. CK1 is involved in a number of cellular processes including DNA repair, cell division, nuclear localization and membrane transport.

CK1 isoforms also have key roles in the developmentally important Wnt and Hedgehog (Hh) signaling pathways. When Wnt is not bound to its receptor, CK1α is thought to phosphorylate β-catenin as part of its ...