Caspase Compounds Small Molecules and Peptides

Caspases (cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED.

Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are ...