CBL Proteins and Enzymes

CBL (Lake Casitas, California mouse B-lineage Lymphoma; also RING finger protein 55) is a 120 - 125 kDa cytosolic member of the CBL family of proteins. It is widely expressed, being found in cells such as fibroblasts, adipocytes, osteoclasts, podocytes and mammary epithelium. CBL negatively regulates RTK signaling by acting as an E3 ubiquitin ligase. Following activation via phosphorylation, CBL will interact with multiple signaling molecules such as Src, ZAP-70, EGFR and SHP1 terminating their activation.