CCR1 is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Human CCR1 is 355 amino acids (aa) in length and has a predicted molecular weight of 41 kDa. Mouse and rat CCR1 share 80% aa sequence identity with the human protein. Most chemokine receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades, including the Akt and NFkB pathways. Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration.