CDNF Proteins and Enzymes

CDNF (conserved dopamine neurotrophic factor), also called Armetl1 (arginine-rich, mutated in early stage tumors-like 1) in mouse, is a secreted protein that shares 62% amino acid identity with human MANF (mesencephalic-astrocyte-derived neurotrophic factor), also called Armet in mouse. Like MANF and GDNF (glial cell-derived neurotrophic factor), CDNF promotes survival of dopaminergic neurons in vitro. In a rat Parkinsons disease model, CDNF also promotes rescue and restoration of dopaminergic neurons in vivo.