Chemokine CXC Receptor Agonists

Chemokine CXC receptors (CXCRs) predominantly recognize CXC chemokines. CXC chemokines are distinguished by having four conserved cysteines, with the first two cysteines being separated by a single amino acid. There are six chemokine CXC receptors, CXCR1 to 6, with each one having a distinct chemokine and leukocyte specificity.

CXCR1 and 2 are expressed on neutrophils and monocytes/macrophages, and are involved in acute inflammation and innate immunity. CXCR3 is expressed on circulating T ...