Chk2 Proteome Profiler Antibody Arrays

The Chk2 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle checkpoints. In response to genotoxic insults Chk2 is phosphorylated by ATM or ATM-related kinases. Phosphorylation of Chk2 T68 promotes the formation of Chk2 oligomers. Oligomerization is a critical event in the activation of the Chk2 kinase as i...