Chymase/CMA1 Proteins and Enzymes

Chymases are a group of chymotrypsin-like serine proteases secreted by mast cells. They are synthesized as inactive precursors containing a 2-residue propeptide, which needs to be removed by dipeptidyl peptidase I/cathepsin C for enzymatic activity. Human chymase encoded by the CMA1 gene is known to be involved in hypertension and heart failure through its ability to convert angiotensin I (Ang I) to angiotensin II (Ang II). In addition, it is also important in physiological and pathological conditions including inflammation, fibrosis and processing of cytokines.