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2 results for "Class I Histone Deacetylases Degraders" in 产品
Class I Histone Deacetylases Degraders
HDAC classification
| Superfamily | Family | Class | Subclass | Protein (human) |
|---|---|---|---|---|
| Arginase/deacetylase superfamily | Histone deacetylase family | Class I | HDAC1, HDAC2, HDAC3, HDAC8 | |
| Class II | Class IIa | HDAC4, HDAC5, HDAC7, HDAC9 | ||
| ClassIIb | HDAC6, HDAC10 | |||
| Class IV | HDAC11 | |||
| Deoxyhypusine synthase like NAD/FAD-binding domain superfamily | Sir2 regulator family | Class III | I | SIRT1, SIRT2, SIRT3 |
| II | SIRT4 | |||
| III | SIRT5 | |||
| IV | SIRT6, SIRT7 |
Selective class I HDAC Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥97% |
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Selective HDAC3 Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide |
| Purity: | ≥98% |
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