Coagulation Factor VII Proteins and Enzymes

Coagulation Factor VII is synthesized in the liver and circulates in the plasma where it binds to tissue factor (TF), an integral membrane protein found in a variety of cell types. The predominant splicing variant of factor VII in normal liver corresponds to the 444 amino acid precursor. After a signal peptide (residues 1 to 38), the mature chain can be further processed into the light chain (residues 39 to 190) and the heavy chain (residues 191 to 444).