CTRP1/C1qTNF1 Proteins and Enzymes

C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. Circulating levels of CTRP1 (C1qTNF1) are elevated in obesity, hypertension, and diabetes but can be decreased in the serum of diet-induced obese mice.