Dectin-1/CLEC7A Proteins and Enzymes

Dectin-1, also known as CLEC7A, is a transmembrane C-type lectin that participates in the innate immune response to fungal pathogens. It is expressed on the surface of monocytes, macrophages, myeloid DC, neutrophils, eosinophils, B cells, and CD4+ T cells. Dectin-1 selectively binds beta-glucan polymers, a major component of yeast and mycobacterial cell walls. Dectin-1 mediates the phagocytosis of zymosan particles and intact yeast. Dectin-1 colocalizes with TLR2 in the presence of zymosan, and the two receptors cooperate in ligand recognition and the propagation of proinflammatory signaling. Dectin-1 also interacts with tetraspanin CD37 which increases its stability on the cell membrane and inhibits ligand-induced signaling.