Desert Hedgehog/Dhh Proteins and Enzymes

Dhh regulates testis development and spermatogenesis via interaction of its N-terminal domain with the receptors Patched and Patched-2. Hedgehog proteins are secreted as precursor molecules that undergo autocatalytic internal cleavage to yield an N-terminal domain that has signaling activity and a C-terminal domain that is active in precursor processing.