2 results for "DOT1L Small Molecules and Peptides" in 产品
DOT1L Small Molecules and Peptides
DOT1L (mammalian counterpart of yeast Dot1) is a nuclear non-SET domain histone H3K79 methyltransferase. It is involved in developmental gene transcription and maintenance of chromatin structure, and may promote mixed lineage leukemia.
Highly potent DOT1L inhibitor
| Chemical Name: | 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% |
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Highly potent and selective DOT1L inhibitor; cell permeable
| Chemical Name: | 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea |
| Purity: | ≥98% |
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