ECSCR CDNA Clones

ECSCR is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. ECSCR may play a role in angiogenesis-related diseases. Alternatively spliced transcripts encoding different proteins have been described.