Eph Receptor Inhibitors Small Molecules and Peptides

Eph (or ephrin) receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB, based on sequence homology and binding affinities. The receptors are widely expressed and are involved in the control of cell positioning, tissue patterning, organ patterning and cell survival.

Both receptor and ligand are membrane bound, so that interaction between the two occurs at sites of cell-cell contact, and uniquely, initiates a bidirectional ...