Exendin-4 Proteins and Enzymes

Exendin-4 is a 39-amino-acid peptide found in venom from the Gila monster Helicoderma suspectum (1). It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion (2).