Furin Inhibitors

Furin Domain Structure, Classification and Biological Role

Encoded by the FURIN gene, furin (also known as PACE or Paired basic Amino acid Cleaving Enzyme) is a Type I transmembrane protein and a member of the proprotein convertase family, which forms part of the subtilisin super family of serine endoproteases.

When expressed, the furin peptide contains a signal peptide, which enables the pro-enzyme to be trafficked into the endoplasmic reticulum (ER). Furin also contains prodomains that are ...