GEN1 Proteins and Enzymes

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-strandedDNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded.Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strandoverhang of the flap is double-stranded