GPR55 Receptor Agonists

GPR55 is a previously orphan receptor that exhibits affinity for endogenous, plant and synthetic cannabinoids, as well as lysophosphatidylinositols (LPIs), which are suggested to be its endogenous ligand. The effects of cannabinoid ligands that are inactive at CB₁ and CB₂, e.g. palmitoylethanolamide, are thought to be mediated through GPR55.

GPR55 is coupled to both the G_α12/13 and the G_αq intracellular pathways and displays complex pharmacology, with ligands having functional ...